Endocrine Abstracts

Ghrelin, a newly discovered and unique peptide hormone activates the growth hormone secretagogue receptor (GHS-R) to potently induce growth hormone release. Ghrelin treatment rapidly increases serum growth hormone concentrations, as well as stimulating food intake in vivo. Our laboratory was the first to demonstrate that ghrelin increases the proliferation of the prostate cancer cell lines PC3 and LNCaP in vitro and that these cells express the GHS-R at the mRNA and protein le...